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Methylation of p53 protein by KMT7/SET7 is the primary reported KMT-mediated methylation event on a non-histone protein 18 Since that discovery, a number of KMTs, as well as KDM1A, have been recognized as p53 regulators that methylate or demethylate p53 protein, making p53 essentially the most extensively studied non-histone protein undergoing lysine methylation 4 , thirteen , 16 , 18 , 162 Right here we use p53 as a mannequin to debate the functions of lysine methylation of non-histone proteins.
Widespread posttranslational modifications include methylation of the ε-amino group, giving methyl- , dimethyl- , and trimethyllysine The latter occurs in calmodulin Different posttranslational modifications at lysine residues include acetylation , sumoylation , and ubiquitination Collagen contains hydroxylysine , which is derived from lysine by lysyl hydroxylase - Glycosylation of hydroxylysine residues in the endoplasmic reticulum or Golgi equipment is used to mark sure proteins for secretion from the cell In opsins like rhodopsin and the visible opsins (encoded by the genes OPN1SW , OPN1MW , and OPN1LW ), retinaldehyde kinds a Schiff base with a conserved lysine residue, and interplay of sunshine with the retinylidene group causes signal transduction in shade vision (See visible cycle for particulars).
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